GIT and GIT surgery

This randomized controlled noninferiority pilot study compared the technical performance of disposable versus reusable colonoscopes in routine colonoscopies. Among 116 patients, both groups achieved a 100% colonoscopy completion rate, confirming the noninferiority of disposable colonoscopes. While disposable devices showed slightly lower performance in imaging and maneuverability, clinical outcomes and safety measures were comparable, suggesting that with continued refinement, disposable colonoscopes could become a practical alternative in specific clinical contexts.

Journal: Digestive Endoscopy

Journal Q value: Q1

Journal Impact factor: 5

Author: Xiao-Ling Wang, Bin-Jia Li, Huo-Wang Ye, Bing-Zhou Wang, Chang-Hui Yu, Shao-Heng Zhang, Dan-Dan Jin, Jian-Lin Yu, Xin-Ying Wang

This study analyzed the exomes or genomes of 129 infants with suspected monogenic congenital diarrheal disorders (CODEs), identifying causal variants in 48% of cases, including a novel founder variant in NEUROG3. Functional studies using cell and zebrafish models led to the discovery and characterization of three novel CODE-associated genes: GRWD1, MYO1A, and MON1A. These findings expand the genetic landscape of CODEs and support the development of precision therapies guided by molecular diagnoses.

Journal: The New England Journal of Medicine (NEJM)

Journal Q value: Q1

Journal Impact factor: 96.2

Author: Zeenat Gaibee, M.D., Neil Warner, Ph.D., Katlynn Bugda Gwilt, Ph.D., Wenjuan Li, Ph.D., Rei Guan, Ph.D., Michael Yourshaw, Ph.D., Ryder Whittaker Hawkins, Ph.D., Christiane Zorbas, Ph.D., Jonathan St.-Germain, Ph.D., Mahdi Tabatabaie, B.Sc., Suli Mao, B.Sc., Vered Pinsk, M.D., Baruch Yerushalmi, M.D., Lee-kai Wang, Ph.D., Stanley F. Nelson, M.D., Laura Wozniak, M.D., Dror S. Shouval, M.D., Manar Matar, M.D., Amit Assa, M.D., Nathaniel Frost, B.Sc., Lissette Jimenez, M.D., Sari Acra, M.D., M.P.H., Thomas Walters, M.D., Stephen Mouat, M.D., Michael Li, B.C.S., Denis L.J. Lafontaine, Ph.D., Matthew Tyska, Ph.D., Brian Raught, Ph.D., Yaron Avitzur, M.D., Wayne I. Lencer, M.D., James R. Goldenring, M.D., Ph.D., Martín G. Martín, M.D., M.P.P., Jay R. Thiagarajah, M.D., Ph.D., and Aleixo M. Muise, M.D., Ph.D.

This phase 2 study investigated neoadjuvant PD-1 blockade with dostarlimab in patients with early-stage mismatch repair–deficient (dMMR) solid tumors eligible for curative surgery. A clinical complete response was achieved in 84 of 103 patients who completed treatment, allowing 82 to avoid surgery, with a 2-year recurrence-free survival rate of 92%. These results support the potential of immunotherapy to enable organ preservation across various early-stage dMMR tumor types without compromising curative outcomes.

Journal: The New England Journal of Medicine (NEJM)

Journal Q value: Q1

Journal Impact factor: 96.2

Author: Andrea Cercek, M.D., Michael B. Foote, M.D., Benoit Rousseau, M.D., Ph.D., J. Joshua Smith, M.D., Ph.D., Jinru Shia, M.D., Jenna Sinopoli, N.P., Jill Weiss, B.S., Melissa Lumish, M.D. https://orcid.org/0000-0003-4173-5567, Lindsay Temple, B.A., Miteshkumar Patel, M.S., Callahan Wilde, B.A., Leonard B. Saltz, M.D., Guillem Argiles, M.D., Zsofia Stadler, M.D., Oliver Artz, Ph.D., Steven Maron, M.D., Geoffrey Ku, M.D., Ping Gu, M.D., Yelena Y. Janjigian, M.D., Daniela Molena, M.D., Gopa Iyer, M.D., Jonathan Coleman, M.D., Wassim Abida, M.D., Seth Cohen, M.D., Kevin Soares, M.D., Mark Schattner, M.D., Vivian E. Strong, M.D., Rona Yaeger, M.D., Philip Paty, M.D., Marina Shcherba, M.D., Ryan Sugarman, M.D., Paul B. Romesser, M.D., Alice Zervoudakis, M.D., Avni Desai, M.D., Neil H. Segal, M.D., Ph.D., Imane El Dika, M.D., Maria Widmar, M.D., Iris Wei, M.D., Emmanouil Pappou, M.D., Ph.D., Gerard Fumo, M.D., Santiago Aparo, M.D., Mithat Gonen, M.D., Marc Gollub, M.D., Vetri S. Jayaprakasham, M.B., B.S., Tae-Hyung Kim, M.D., Julio Garcia Aguilar, M.D., Ph.D., Martin Weiser, M.D., and Luis A. Diaz, Jr., M.D.